The primary goal of this project is to investigate the link between EBV and MS using a virtual clinical trial framework by testing three hypotheses: EBV resurgency, impaired B cell regulation, and molecular similarity between EBV antigens and myelin in genetically predisposed individuals.

The team has developed a within-host mathematical model of EBV infection, building on existing frameworks that incorporate epithelial and B cell dynamics, to examine which mechanisms are most likely to drive disease onset, with a current focus on immune cross-reactivity. The model will be further extended to include autoreactive immune responses and myelin damage, providing a more comprehensive representation of MS-related pathology.

During her visit, Ryu also delivered a colloquium talk titled 鈥淚mmune Dysregulation in COVID-19: What Can Mathematical Modeling Tell Us?鈥� based on her recently published work supported by the National Science Foundation. In the talk, she addressed why some individuals experience mild COVID-19 while others develop severe disease, presenting a mathematical framework that captures interactions between SARS-CoV-2 and the immune system. Through computational simulations and sensitivity analysis, she demonstrated how variations in immune responses can lead to divergent disease trajectories and highlighted key mechanisms that influence disease progression.

Following her time in Sydney, Ryu will travel to the University of Melbourne in late April to help organize a two-week workshop, 鈥淐ollaborative Workshop for Under-Represented Genders Advancing Mathematical Biology,鈥� co-organized with Jenner. This will be held at for the mathematical sciences in Australia near the campus of the University of Melbourne.

These visits provide valuable opportunities to advance interdisciplinary collaboration and strengthen international research connections in mathematical biology.

Visiting Assistant Professor of Mathematics and Statistics Keta Henderson gave an invited talk on her collaborative work titled 鈥淎nalysis of trade-off between dispersal and patch intrinsic growth for a landscape ecological model exhibiting Weak Allee effect growth鈥� in a special session on advances and applications in integral and differential equations.

Assistant Professor of Statistics Andre Waschka presented his work titled “A Semi-Parametric Bootstrap Simulation Using Causal Machine Learning”聽 in a contributed paper session.

Butterbach鈥檚 path to research started in a cell biology course taught by Assistant Professor of Biology Efrain Rivera-Serrano, where she consistently asked questions and engaged deeply with the material. This curiosity led her to join the interdisciplinary project.

鈥淚t was a very 鈥榬ight place, right time鈥� circumstance,鈥� Butterbach said. 鈥淭his research was exactly the sort of thing I was looking to get involved in.鈥�

Through her Lumen Prize, Butterbach is working alongside two faculty mentors from different fields of study, Associate Professor of Mathematics Hwayeon Ryu and Rivera-Serrano, to study viral myocarditis, or heart inflammation, that occurs during the infection of many viruses. Her research is focused on examining the pathways that lead to excessive inflammation and how inflammation can be reduced without compromising the immune system鈥檚 ability to clear the virus.

鈥淢y research focuses on creating math out of biological reactions,鈥� Butterbach said. 鈥淯ltimately, the goal is to create a framework that helps us better understand and predict how cardiac inflammation progresses.鈥�

Viral myocarditis occurs when inflammation damages heart tissue, sometimes leading to long-term complications or sudden cardiac failure, particularly in young, active individuals. Although inflammation is a natural immune response, Butterbach鈥檚 research is exploring what causes that response to become excessive.

Butterbach uses mathematical modeling to integrate biology and immunology into a modeling framework to identify factors that most strongly drive harmful inflammation, revealing pathways that could be therapeutically targeted.

鈥淚t鈥檚 a balancing act to use equations to model what鈥檚 happening,鈥� Butterbach said. “If the model is too simple then it is not realistic to the human heart, but if the model is too complex, it becomes difficult to work with.鈥�

Taking an interdisciplinary approach

This research project鈥檚 strength lies in its collaboration and intersection between mathematics, biology and engineering. Mathematics offers the language and tools to create the models, while biology provides the foundation for understanding the disease. Engineering ties it together through design, problem-solving and a systems-level mindset.

鈥淭his project works precisely because it sits at the intersection of all three areas,鈥� Rivera-Serrano said. 鈥淓lise is especially well suited for this work because she is genuinely interested in connecting these disciplines rather than treating them as separate silos.鈥�

Ryu echoed this statement on Butterbach鈥檚 interdisciplinary approach.

鈥淓lise approaches research with a rare combination of intellectual curiosity, maturity and persistence, and she is genuinely committed to understanding how mathematics and biology inform one another,鈥� Ryu said. 鈥淗er ability to engage across disciplines and contribute thoughtfully at that intersection is what makes her such a strong and promising researcher.鈥�

Butterbach, Rivera-Serrano and Ryu meet weekly to refine their model, troubleshoot challenges and discuss literature.

鈥淭he steady back-and-forth is one of the strengths of the project,鈥� Rivera-Serrano said.

For Butterbach, working across disciplines has shaped how she approaches problems.

鈥淚鈥檝e always found that when different disciplines collide, it actually becomes easier to understand complex concepts,鈥� Butterbach said. 鈥淲orking across engineering, mathematics and virology is fascinating because each discipline approaches the same problem in a completely different way. Learning to think adaptively across disciplines and translate between them has been one of the most valuable parts of this experience.鈥�

Butterbach is motivated by the possibility of using interdisciplinary research to better understand human disease.

鈥淭he interdisciplinary nature and the way the team bring together mathematics, biology and engineering is not always easy to achieve, but Elise has embraced it fully and become an essential part of that process,鈥� Ryu said.

Collaborating on this research has been rewarding not only for Butterbach, but for her mentors as well.

鈥淲orking with Elise has been incredibly rewarding,鈥� Rivera-Serrano said. “She approaches a difficult project that requires her to be conversant in multiple disciplines with curiosity, maturity and persistence.鈥�

One takeaway she learned from working in disciplines outside of her major is that discoveries in one field almost always influence others.

鈥淏y learning how to think like a biologist, a mathematician and a physicist, I have become much more comfortable applying ideas from one subject to another, even when they seem unrelated at first.鈥�

She also values the work with her two mentors, Rivera-Serrano and Ryu, as they have helped her grow as a researcher.

鈥淒r. E spends a lot of time looking for resources that I can use to calculate the values of different parameters,鈥� Butterbach said. “Similarly, Dr. Ryu works tirelessly to not just improve my mathematical skills but also teaches me how to see mathematical theory working in the real world. They鈥檙e not just dedicated to this project; they鈥檙e also thinking about what comes next for me.”

Expanding her research

Butterbach was recently selected for a competitive Physical, Engineering and Biology Research Experiences for Undergraduates program at Yale University, focused on physics, engineering and biology. Butterbach hopes to expand her research on the cardiovascular system.

鈥淓lise鈥檚 acceptance is especially meaningful because it reflects national-level recognition of her promise as an undergraduate researcher in an interdisciplinary space,鈥� Rivera-Serrano said.

For Butterbach, the opportunity was surprising and motivating.

鈥淚 tried not to set any grand expectations for myself, so when I received the email I was genuinely surprised to be selected for the program,鈥� Butterbach said. 鈥淚t felt incredibly validating of the hard work and dedication I鈥檝e put into my studies.鈥�

At Yale, the program, like her research, is interdisciplinary covering biology, physics and engineering. She will expand her experience in computational and biological modeling while working alongside researchers.

鈥淭o me, this program represents the opening of new doors,鈥� Butterbach said. 鈥淚t鈥檚 an opportunity to continue growing as a researcher, meet people working at the forefront of interdisciplinary science and explore new directions that I may not have encountered otherwise.鈥�

Clark is a past NC State Director, past Webmaster and past Chair of the Section, and currently chairs its Bylaws Revision Committee. After two years of work on the revision the Section voted its approval of the revision at its Business Meeting on March 27. The bylaws revision not only streamlines the organization’s governance but also builds more diversity and inclusion into its processes聽through how it structures its selection committees.

Clark presented “A (Nearly) Infinitesimally Quick Introduction to the Surreal Numbers” at the meeting on March 28.

While at the conference he also attended talks on the impact of AI on mathematical pedagogy as well as various software packages supporting new mathematical texts.

There were many Pi-themed entries, but Professor Heather Barker’s mini strawberry pies with the digits of Pi written on each pie took the award for Best Tasting Bake. Math major Tyler Rosen’s savory meat pies won the award for Most Pi Bake.

Following the Bake Off, the party went outside for the main Pie-Your-Professor event. Students could spin the wheel with equal odds of: pie a professor, pie a student, Professor of Statistics Laura Taylor, or the students get pied.

Five faculty members from the Math and Stats department (Todd Lee, Nancy Scherich, Laura Taylor, Ryne VanKrevelen and Larry Cantwell) and three students (Tyler Rosen, Kelly DonovanAndrew Pipeling) volunteered to be the pie-ees.聽 All volunteers got pied, and some got pied more than once.

The colloquium lecture was titled “Knots and Braids with a Little Bit of Dance.” Scherich started off the lecture with an introduction to the mathematical field of knot theory, which is a subfield of topology. She showed her Math-Dance video “Algebra, Geometry, and Topology; What’s the difference?” which explains how the three fields of mathematics are different. (You can watch the video .)

Twenty minutes into the lecture, Song took over the lecture to discuss their collaborative knot theory research project that they have been working on for a three semesters. The lecture concluded with Scherich returning to the stage to discuss her research about the danceability index, which is another student project she has been working on for two years with alumni Sol Addison ’25 and Lumen Scholar Lila Snodgrass ’26.

The competition included 17 teams, from 9 schools, and each team presented their work for judges from professional baseball teams and companies. Teams were given one week to develop an analytics-based approach to determine when certain power hitters should adjust their plan at the plate to favor more contact. The teams needed to decide on an approach, gather and clean data, analyze the data, and produce a 20-minute presentation during that time. 黑料不打烊鈥檚 team collected data from four different sources to build a model accounting for batter and pitcher ability, situational importance, ballpark-specific factors, and weather. Part of their approach included using existing situations where batters might already adjust their plan to determine which hitters have the greatest capacity to make adjustments.

黑料不打烊 has been sending a team to this competition for a decade, and several former members have secured jobs with professional baseball teams after graduation. Jackie Jovanovic 鈥�23, who represented 黑料不打烊 in the competition twice, returned this year as a judge for the competition. She is now working for the Miami Marlins as a Junior Data Scientist.

The Baseball Analytics Club meets weekly throughout most of the year and is mentored by Ryne VanKrevelen, associate teaching professor of statistics. Students interested in joining the club or learning more should reach out to VenKrevelen.

Student participation in the conference was supported by the School of Communication, College of Arts and Sciences, Mathematics and Statistics Department and Data Nexus. The five-member team will present their work at the Spring Undergraduate Research Forum (SURF) in April.

This article investigates how the human immune system responds to SARS-CoV-2 infection, with a particular focus on natural killer cells and cytokine regulation and their roles in determining disease severity. Using a mathematical, within-host model that combines viral dynamics with immune interactions, the study explores how different immune responses can lead to either viral clearance or severe inflammation. The findings provide insight into key immune mechanisms and offer guidance for identifying potential targets for future COVID-19 treatments. This work is a result of聽a聽National Science Foundation-funded project听辞苍听COVID-19 mathematical modeling.

is an interdisciplinary journal promoting cutting-edge research, technology transfer and knowledge translation about complex data and information processing at the interface of mathematics, biology, medicine and engineering.

Since his 2023 arrival at 黑料不打烊, Kelly has hosted a 鈥榣istening tour鈥� and spent time with each department to hear directly from faculty and staff about what they value. Kelly said that common themes soon emerged from those conversations and the new statement reflects dozens of discussions.

黑料不打烊 College, the College of Arts and Sciences new vision statement reads: 鈥淭he Heart of an 黑料不打烊 Education: Ignite Curiosity, Engage Challenges, Transform Worlds.鈥�

The mission statement then declares:

鈥淯pholding the centrality of the liberal arts, we explore and apply disciplinary and interdisciplinary knowledge for inquiry, creativity, discovery and problem solving in a complex and changing world.鈥�

The statement lists core values that include accessibility, belonging, critical thinking, diversity, equity and inclusion, integrity, intellectual curiosity, problem-posing and respect for human dignity.

Community Reflections

• 鈥淭here were several opportunities for different groups, departments, branches, interdisciplinary programs, to discuss versions on the table. It was in those conversations where we might learn how a word or phrase was heard within and across disciplines; where we found convergence, deeper awareness, and respect. The both-and of this process modeled what we value and genuinely captures our shared identity as 黑料不打烊 College.鈥� – Caroline Ketcham, associate dean of 黑料不打烊 College, the College of Arts and Sciences and a professor of exercise science
• 鈥淚t was always important to us that this wasn鈥檛 a process where faculty were just asked to weigh in at the end, after the real decisions had already been made. From start to finish, it was grounded in listening to what faculty across the college say we do well and what values they believe guide our shared work. Our task wasn鈥檛 to invent a mission, vision and values, but to clearly articulate what faculty are already living and leading with. I think that鈥檚 why faculty can so readily see themselves and their departments represented in the final statements.鈥� – David Buck, associate dean of 黑料不打烊 College, the College of Arts and Sciences and an associate professor of psychology
• 鈥淗aving shared goals and articulated values helps everyone in the college feel connected as a community, value each other鈥檚 work and prioritize our energies on initiatives that matter to us.鈥� – Shannon Duvall, interim associate dean of 黑料不打烊 College, the College of Arts and Sciences and professor of computer science
• 鈥淚 appreciated the collaborative nature of it all, not just between the dean鈥檚 office and department chairs, but also extending to faculty members across 黑料不打烊 College, the College of Arts and Sciences. It really did involve all of us. What particularly stood out to me were the conversations in our chairs鈥� meetings with the dean where we came to agreements on core values. It鈥檚 inspiring to see that distinctly different types of disciplines uphold the same core values.鈥� – Joel Karty, chair of the Department of Chemistry and 黑料不打烊鈥檚 Sydney F. & Kathleen E. Jackson Professor of chemistry
• 鈥淚 appreciated being part of a process that felt genuinely collaborative. Our participation was not merely symbolic. It felt meaningful, and I experienced the dean鈥檚 office as truly listening. The process itself was also inspirational, and I feel bolstered in leading my own department through similar work. It was powerful to see such a broad, collective effort take shape into something tangible.鈥� – Samantha DiRosa, chair of the Department of Art and a professor of art and environmental studies
• 鈥淭he process of creating a new vision statement, mission statement and core values for 黑料不打烊 College, the College of Arts and Sciences was both thoughtful and deeply collaborative. Over many months, department chairs worked together to reflect on what makes us distinctive and how best to express those qualities in guiding statements. The process intentionally sought input from across departments, ensuring that everyone in the college had the opportunity to contribute their perspectives. Personally, the time spent reflecting with fellow chairs on what makes each of our departments special fostered a deeper sense of shared purpose and collective commitment.鈥� – Carrie Eaves, chair of the Department of Political Science and Public Policy and associate professor of political science and public policy

Kelly said he was pleased the final language resonated with the faculty in the college.

鈥淭he true measure of a successful attempt to lead a group or an organization towards a renewed vision, mission and core values is whether the words and sentiments 鈥榮ound like us鈥�,鈥� he said. 鈥淲hen I heard that some faculty believed my presentation of our vision, mission and core values at our spring faculty meeting 鈥榮ound like us,鈥� I knew that our work together in small and large group settings was a huge success. It means that stakeholders were heard and that the words resonate so much so that the tune or melody is familiar. The vision, mission and core values reflect truly who we are and where we are going with much intention.鈥�