Hwayeon Ryu, associate professor of mathematics, published a paper in Mathematical Biosciences on investigating bistable dynamics arising from macrophage鈥搕umor interactions in the tumor microenvironment.
Associate of Mathematics Hwayeon Ryu has published a peer-reviewed paper entitled 鈥淢odeling bistable dynamics arising from macrophage鈥搕umor interactions in the tumor microenvironment鈥 in “Mathematical Biosciences,” one of top-tier journals in the field of mathematical biology.
This work was from international collaboration with three other mathematical biologists including聽Susanna R枚blitz at the University of Bergen in Norway, partially funded by聽聽through its Structured Quartet Research Ensembles program and 黑料不打烊 Faculty Research & Development Full-Year, Full-Pay Sabbatical Award with Financial Assistance. In this collaboration, Ryu (serving as the first as well as corresponding author) and co-authors develop and analyze a mathematical model to describe the temporal evolution of the tumor volume alongside different phenotypes of tumor-associated macrophages (TAMs), which extends their previous work on聽a single-cell model in the absence of tumors.聽Our new population-level modeling approach allows for investigating聽the impact of TAMs on tumor growth and tumors鈥 control of TAM phenotypes.聽To that end, model results are linked to treatment strategies that manipulate the bistable system to transition from high to low tumor volume.
,聽established in 1967,聽is one of highly cited, top-tier journals in the field of mathematical biology. It is a聽monthly peer-reviewed scientific journal covering work that provides new concepts or new understanding of biological systems using mathematical models, or methodological articles likely to find application to multiple biological systems.