Hwayeon Ryu, assistant professor of mathematics, published a paper in Journal of Theoretical Biology on investigating stochastic behaviors in the macrophage differentiation process.
Assistant Professor of Mathematics Hwayeon Ryu has published a peer-reviewed paper entitled 鈥淢acrophage phenotype transitions in a stochastic gene-regulatory network model鈥 in Journal of Theoretical Biology, one of prestigious journals in the field of computational biology.
This work was from international collaboration with three other mathematical biologists including聽 and Anna Frank, both at the University of Bergen in Norway, partially funded by聽聽through its three-year聽Structured Quartet Research Ensembles program. In this collaboration, Ryu and co-authors develop and analyze a stochastic model for macrophage phenotype transitions, which extends their previous paper on .聽Our new approach allows for a probabilistic interpretation of macrophage phenotype transitions and biological inference on phenotype robustness. In general, the methodology can easily be adapted to other systems where random state switches are known to occur.
,听established in 1961,听is one of highly cited, top journals in the field of computational biology. It is a聽biweekly peer-reviewed scientific journal covering theoretical biology, as well as mathematical, computational and statistical aspects of biology. Some research areas covered by the journal include cell biology, evolutionary biology, population genetics, morphogenesis, and immunology.
A. S. Frank, K. Larripa,听H. Ryu, and S. R枚blitz, ,听Journal of Theoretical Biology, 575:111634, 2023